Multiple Sclerosis: Tempering Disabilities and Decline
Fundamentals for Managed Markets

On-Demand Slide Lecture with Audio/Monograph

Sponsored by North American Center for Continuing Medical Education, LLC

On-Demand Slide Lecture Presenter/Q&A Cohost

Howard Zwibel, MD
Founding Medical Director, Emeritus
Neuroscience Consultants
Comprehensive Multiple Sclerosis Center
Coral Gables, Florida

On-Demand Slide Lecture Q&A Cohost/Monograph Managed Care Commentary Contributor

William J. Cardarelli, PharmD
Director of Pharmacy
Atrius Health
Harvard Vanguard Medical Associates
Watertown, Massachusetts

Monograph Clinical Commentary Contributor

Heidi Crayton, MD
Medical Director
Multiple Sclerosis Center of Greater Washington
Vienna, Virginia
Assistant Professor of Neurology
Georgetown University Hospital
Washington, DC

Target Audience

This activity is designed for managed markets physicians and pharmacists.

Learning Objectives

After completing this activity, participants should be able to:

• Describe the progressive nature of multiple sclerosis (MS)-related disability and comorbidities and the impact on quality-of-life and healthcare resource use
• Outline the evidence for the current and potential role of available and emerging therapies on MS symptom control and disease progression
• Put into practice current MS knowledge and treatment options to optimize health plan decisions and assist in improving outcomes

Activity Overview

The on-demand slide lecture with audio is available with html slides and the presentation transcript. The monograph is available in print and PDF format.

To be eligible for documentation of credit, participants must complete one of the educational activities, complete the 10-question online posttest with a score of 70% or better, and complete the evaluation form. After successful completion of the post-test and evaluation form online at www.naccme.com, participants may immediately print their documentation of credit.

There is no fee associated with this activity.

Participants who have successfully completed the live version of this activity are not eligible to receive credit for these enduring materials.

Release Date: November 13, 2009

Expiration Date: December 15, 2010

Estimated time to complete: 1 hour

For questions regarding this educational activity, please contact Angela Scarnici at 609-371-1137.

Hardware/Software Requirements

All educational activities are accessible via a computer 650 MHz PC, 128 MB RAM, Windows or MAC operating system, Internet Explorer, Netscape, or Safari browsers. Windows Media Player, sound card, and speakers are required for streamed audio. Flash Player, sound card, and speakers are required for video programs. A PDF reader is required for print publications. Please direct technical questions to webmaster@naccme.com.

This educational activity is a knowledge-based activity.

CME Accreditation

North American Center for Continuing Medical Education, LLC (NACCME) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

NACCME designates each educational activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

CPE Accreditation

North American Center for Continuing Medical Education, LLC (NACCME) is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This activity is approved for 1 contact hour (0.1 CEU) of continuing pharmacy education (UAN 276-000-09-031-H01-P).

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact John Savage, Director, Medical Education, NACCME, in writing at 300 Rike Drive, Suite A, Millstone Township, NJ 08535, or by e-mail at jsavage@naccme.com. The Director of Medical Education will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Vice President, Medical Education, NACCME, may be made for a second level of review.

Independent Clinical Reviewer: Darin T. Okuda, MD, Assistant Professor of Neurology, UCSF Multiple Sclerosis Center, San Francisco, California

Medical writer Deborah Neveleff contributed to the writing and editing of the monograph article.

Planning Committee

The planning committee comprises Howard Zwibel, MD, William J. Cardarelli, PharmD, Heidi Crayton, MD, Darin T. Okuda, MD, Deborah Neveleff; and Randy Robbin, Rosemary Hodgson, Emilie McCardell, John Savage, and William Kormos, NACCME.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are indentified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

The faculty has reported the following:

Dr. Zwibel: Scientific Consultant—Genentech Inc, Teva Pharmaceutical Industries Ltd, Bayer HealthCare; Promotional Speakers’ Bureau—Teva Pharmaceutical Industries Ltd

Dr. Cardarelli has disclosed no relevant financial relationships with any commercial interests.

Dr. Crayton: Scientific Consultant—Biogen Idec Inc, Teva Pharmaceutical Industries Ltd; Promotional Speakers’ Bureau—Biogen Idec Inc; Grant/Research Support—Biogen Idec Inc, Genzyme Corporation

Dr. Okuda: Promotional Speakers’ Bureau—EMD Serono Inc

Mr. Robbin, Ms. Hodgson, Ms. McCardell, Mr. Savage, Mr. Kormos, and Ms. Neveleff have disclosed no relevant financial relationships with any commercial interests.

NACCME requires faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

Faculty has disclosed that the use of fampridine, amantadine, modafinil, methylphenidate, and botulinum-toxin for symptom management of multiple sclerosis will be discussed.

Privacy Policy

NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. NACCME and our joint sponsors will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting purposes to the appropriate reporting agency.

NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright ©2009 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing medical education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education.

Grant Support

Supported by an educational grant from Acorda Therapeutics, Inc.